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Beilstein J. Org. Chem. 2012, 8, 1788–1797, doi:10.3762/bjoc.8.204
Graphical Abstract
Figure 1: Flow cytometric uptake studies of carboxyfluorescein-labeled (sC18)2 in HEK-293 (human embryonic ki...
Figure 2: Top: Fluorescence microscopic images of unfixed HEK-293 cells after 30 min incubation with 1 µM CF-...
Figure 3: Cell viability of different cell lines after 24 h incubation with (sC18)2 at different concentratio...
Figure 4: Cell lysis of HEK-293 cells induced by (sC18)2 after 1 h incubation. Experiments were conducted in ...
Scheme 1: Synthesis of (sC18)2 bioconjugates (a) and chemical structures of the coupled anti-tumor agents (b)...
Figure 5: Chromatogram and ESI-MS of purified Cym2-GFL-(sC18)2. The gradient was 10→60% acetonitrile in water...
Figure 6: Circular dichroism spectra of the (sC18)2 conjugates. Spectra were acquired in 10 mM phosphate buff...
Figure 7: Cell viability of (a) HT-29 and (b) MCF-7 cells after 24 h incubation with the (sC18)2 conjugates a...
Figure 8: Brightfield microscopic images of unfixed HT-29 cells after 24 h incubation with the (sC18)2 conjug...
Figure 9: Cell lysis of (a) HT-29 and (b) MCF-7 cells induced by the (sC18)2 conjugates at different concentr...